In a fast urbanising world, cities and metropolitan regions increasingly face challenges of sustainability and quality of life challenges that put at risk issues of mobility and logistics, water and waste management, energy and food security, health and wellbeing. A new two-year master programme Metropolitan Analysis, Design and Engineering (MSc MADE) integrates analysis, design and engineering; the physical, digital and social environments; and the city and its citizens. These challenges are motivating science and society to approach metropoles differently. Advanced metropolitan solutions are being made possible by today’s revolution of new technologies, theories and methods. But no actor or stakeholder can make metropoles move in one certain direction. Metropolitan solutions require cooperation between knowledge institutes, companies, governments, between cities, citizens and civil society.